Boltz
Use Boltz in Codex to predict biomolecule structures, screen molecules and design protein binders.
What Boltz can do in ChatGPT
Model, screen and design biomolecules.
Structure Prediction
Predict structures for protein, RNA, DNA and ligand complexes.
Binding Prediction
Estimate how strongly molecules bind to a target.
Library Screening
Rank small molecules or proteins against a target.
Binder Design
Design peptides, antibodies, nanobodies and custom protein binders.
ADME Checks
Check small molecule candidates with an ADME skill.
You stay in control
You approve access, and you can disconnect Boltz at any time.
What Boltz does in ChatGPT
The Boltz plugin brings Boltz biomolecular modeling into Codex. It predicts the 3D structure of proteins, RNA, DNA and small molecules, and how well they bind to each other. Researchers can run these jobs by describing them instead of setting up each step by hand.
It can also rank a library of small molecules or proteins against a target to find the most promising ones, and design new small molecules, peptides, antibodies, nanobodies or custom protein binders. Results come back with structures and confidence scores.
The listed skills include setting up the Boltz command-line tool, checking job status, protein design and screening, small molecule design and screening, ADME checks for small molecules, and structure and binding prediction. The listing names Codex, OpenAI's coding agent, as the place where it runs.
Built-in skills
The listing says Boltz comes with 1 skills. Skills are ready-made instructions ChatGPT can use for a specific job.
- Boltz Check StatusBoltz CLI SetupBoltz Protein DesignBoltz Protein ScreenBoltz Small Molecule ADMEBoltz Small Molecule DesignBoltz Small Molecule ScreenBoltz Structure and Binding
Who it is for
- Drug discovery researchers
- Computational biologists and chemists
- Protein design teams
How to add Boltz to ChatGPT
- Open the Boltz listing in ChatGPT ↗.
- Click Install plugin.
- Sign in to your Boltz account when asked and approve the access it requests.
- Start a chat and ask for what you need, mentioning Boltz if ChatGPT does not pick it up.
- To stop, disconnect Boltz under apps in your ChatGPT settings.
Questions about Boltz
What is the Boltz ChatGPT plugin?
The Boltz plugin brings Boltz biomolecular modeling into Codex. It predicts the 3D structure of proteins, RNA, DNA and small molecules, and how well they bind to each other. Researchers can run these jobs by describing them instead of setting up each step by hand. It is listed in ChatGPT's plugin marketplace under Scientific Research.
What can I ask Boltz to do in ChatGPT?
For example: "Predict the structure of this protein and ligand complex", "Screen this list of small molecules against my target protein", "Design a nanobody that binds to this antigen". It also comes with built-in skills such as Boltz Check StatusBoltz CLI SetupBoltz Protein DesignBoltz Protein ScreenBoltz Small Molecule ADMEBoltz Small Molecule DesignBoltz Small Molecule ScreenBoltz Structure and Binding.
Who makes the Boltz plugin for ChatGPT?
The ChatGPT listing names Boltz as the developer. The version listed on 8 October 2026 was 0.1.1.
How do I add Boltz to ChatGPT?
Open the Boltz listing in ChatGPT, click Install plugin, sign in to your Boltz account and approve the access it asks for. Then ask for what you need in a chat, mentioning Boltz if ChatGPT does not pick it up.
Can Boltz change things in my account, or only read?
The listing marks it as interactive with write access. It sets up the Boltz CLI and runs modeling, screening and design jobs.
Who is the Boltz plugin for?
Drug discovery researchers, computational biologists and chemists and protein design teams.
Does Boltz run in ChatGPT or Codex?
The listing describes using Boltz from Codex for biomolecular modeling work.
What do results include?
Predicted structures together with confidence scores for the prediction or design.
Does Boltz see my ChatGPT chats?
When Boltz is connected, ChatGPT may share the parts of your chats and memories that matter for a request with Boltz. What Boltz does with that data falls under its own terms and privacy policy. ChatGPT keeps your training-data settings, and you can disconnect at any time.
How do I disconnect Boltz from ChatGPT?
Open your ChatGPT settings, go to apps, and disconnect Boltz. You can reconnect later from the listing.
What are alternatives to Boltz in ChatGPT?
Similar plugins in the ChatGPT marketplace include Rosalind Workbench, Biological Sequence & Alignment Viewer and Life Sciences Databases. Each has its own page in this directory.
Privacy and your data
When Boltz is connected, ChatGPT may share the parts of your chats and memories that matter for a request with Boltz. What Boltz then does with that data falls under its own terms and privacy policy, not only OpenAI's. ChatGPT keeps your training-data settings for data that comes from connected apps, and you can disconnect at any time.